- Title
- Association of antiretroviral therapy adherence and Development of cardiovascular desease risk
- Creator
- Fihla, Qhayiya Mteto
- Description
- IAntiretroviral therapy (ART) is the standard treatment for human immunodeficiency virus (HIV). The treatment reduces HIV load to low level, relegating the disease from an acute infection to a chronic condition. Of late, there have been increased reports associating ART with increased cardiovascular disease (CVD) risk, further reducing the possibility of complete positive health outcomes for people living with HIV (PLWH). Poor adherence to the ART has been implicated in the development of some CVD risk factors but levels of adherence is not well known in the Eastern Cape. Thus, this study was designed to determine the level of ART adherence and associated cardiovascular risk factors. A cross-sectional study of a 100 participants was conducted to determine ART adherence and prevalence CVD risk factors in Mthatha. Both Male and female participants above 18 years of age were selected and ART adherence was determined using the adherence in chronic diseases scale (ACDS). The lipid profile, anthropometric measurements, and clinical parameters were used to determine CVD risk factors. Regression models were fitted to determine the association between adhrence and CVD risk factors in PLWH. All statistical analysis was performed using the statistical package for social sciences (SPSS) version 28, and the statistical significance was set at The average adherence rate was found to be 90.35% population of PLWH sampled, and 30% participants were found to have the optimum adherence rate ≥95%, which considered be adequate to effect viral progression. The prevalence of CVD risk factors was found to be 97%, with 46% of the participants having CVD. Although it was not statistically significant, the regression analyses indicated that non-adherent patients were more likely to report presence of CVD risk factors. This suggests that sub-optimal adherence to ART may be a contributing factor towards CVD risk development in patients on ART. It is possible that the results are clinically significant but there is a need to collect more data to increase the statistical power of the study
- Description
- Thesis (Masters) -- Faculty of Medicine and Health Sciences, 2023
- Date
- 2023-12
- Type
- Masters theses, text
- Identifier
- http://hdl.handle.net/11260/12894
- Identifier
- vital:76176
- Format
- computer, online resource, application/pdf, 1 online resource (80 pages), pdf
- Publisher
- Walter Sisulu University, Faculty of Medicine and Health Sciences
- Language
- English
- Rights
- Faculty of Medicine and Health Sciences, All Rights Reserved, Open Access
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Fihla,QM Dissertation corrected (1).pdf | 1 MB | Adobe Acrobat PDF | View Details |