- Title
- A Comparative Analysis of PSA Trends of Conventional vs Hypo-fractionated External Beam Radiotherapy for the Treatment of Localised Prostate Cancer at Frere Hospital
- Creator
- Mistry, Himal
- Description
- External beam radiotherapy with a moderate hypofractionated regimen has largely replaced conventional schedules. The change in regimen is based on the premise that prostate cancer, due to its low the alpha/beta ratio, demonstrates a higher sensitivity to a larger dose per fraction of radiation. Prostate Specific Antigen (PSA) is a specific indicator of prostate cancer treatment outcomes. The serum PSA trend is an indication of treatment response and risk for relapse. The time to nadir and the value of the PSA nadir are important predictors of biochemical control or failure. The lower the PSA level, the more durable the probability of maintained biochemical disease free survival. This study focuses on the biochemical control of patients treated with two different fractionation regimens at Frere Hospital. Aim To illustrate that the use of a moderate hypofractionated regimen for the treatment of intermediate and high risk prostate cancer is non inferior to a conventional regimen. Methodology The study took place at the department of radiation oncology, Frere Hospital, East London, Eastern Cape, South Africa. The study population consisted of 26 patients treated with conventional fractionation (2.00Gy x 36 fractions) in 2018 and 36 patients treated with the newly adopted hypofractionated regimen (3.00Gy x 20 fractions) in 2019. A comparison is made of the post treatment PSA trend over a 24 month period. Impact of study The study is projected to support the change in fractionation regimens at an institutional level. 2 Results: 41.9% of patients were enrolled in the conventional regimen, 58.1% were enrolled in the moderately hypo-fractionated arm. The participants were classified into high risk and intermediate risk in the two treatment arms and these were distributed equally. There was a clear decline in the serum PSA values over the two-year follow-up period. All four groups showed a similar pattern in that from the baseline to the first quarter, there was a sharp decline in the serum PSA values and this was significant for all four groups
- Description
- Thesis (Masters) -- Faculty of Medicine and Health Sciences, 2023
- Date
- 2023-10
- Type
- Masters theses, text
- Identifier
- http://hdl.handle.net/11260/12906
- Identifier
- vital:76177
- Format
- computer, online resource, application/pdf, 1 online resource (59 pages), pdf
- Publisher
- Walter Sisulu University, Faculty of Medicine and Health Sciences
- Language
- English
- Rights
- Faculty of Medicine and Health Sciences, All Rights Reserved, Open Access
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Himal Mistry.pdf | 1019 KB | Adobe Acrobat PDF | View Details |