- Title
- Gender and Drug-Resistant Tuberculosis in Nigeria
- Creator
- Oladimeji, Olanrewaju
- Creator
- Atiba, Bamidele Atiba
- Creator
- Anyian, Felix Emeka
- Creator
- Odugbemi, Babatunde A
- Creator
- Afolaranmi, Tolulope
- Creator
- Zoakah, Ayuba Ibrahim
- Creator
- Horsburgh, Robert C
- Description
- We conducted a retrospective study of 2555 DR-TB patients admitted to treatment between 2010 and 2016 in six geopolitical zones in Nigeria. We characterized the gender distribution of DR-TB cases and the association between demographics and clinical data, such as age, treatment category, number of previous TB treatment cycles, and geopolitical zone, with gender. The independent effects of being a male or female DR-TB patient were determined using bivariate and multivariate analyzes with statistical significance of p 0.05 and a 95% confidence interval. Records from a total of 2555 DR-TB patients were examined for the study. A majority were male (66.9%), largest age-group was 30–39 years old (35.8%), most had MDR-TB (61.4%), were HIV-negative (76.6%), and previously treated for TB (77.1%). The southwest treatment zone had the highest proportion of DR-TB patients (36.9%), and most DR-TB diagnoses occurred in 2016 (36.9%). On bivariate analysis, age, HIV status, treatment zone, and clinical patient group in DR-TB were significantly associated with male gender. On multivariate analysis, males aged 20–29 years (AOR: 0.19, 95% CI: 0.33–0.59, p = 0.001) and HIV-positive males (AOR: 0.44, 95% CI: 0.33–0.59, p = 0.001) had lower likelihood of MDR-TB as males in the south–south treatment zone (AOR: 1.88, 95% CI: 1.23–2.85, p = 0.03), and being male and aged ≥60 years (AOR: 2.19, 95% CI: 1.05–4.54, p = 0.036) increased the probability of DR-TB. The older male population from south–southern Nigeria and women of childbearing age had lower incidence of DR-TB than men of the same age. Tailored interventions to reduce HIV and DR-TB prevalence in the general population, particularly among women of childbearing potential, and treatment support for young and older men are relevant strategies to reduce DR-TB in Nigeria.
- Date
- 2023/02
- Subject
- drug-resistant TB
- Subject
- gender
- Subject
- treatement zone
- Subject
- human immunodeficiency virus
- Type
- Article
- Identifier
- http://hdl.handle.net/11260/13321
- Identifier
- vital:78424
- Identifier
- DOI: https://doi.org/10.3390/tropicalmed8020104
- Language
- English
- Relation
- Tropical Medicine and Infectious Disease
- Relation
- Tropical Medicine and Infectious Disease 8 vol 2 1 11 2023 https://doi.org/10.3390/tropicalmed8020104
- Rights
- ©2023, authors
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