Emerging pests and Vector-borne diseases in Europe, Volume 1, W. Takken and B.G.J. Knols (Eds.): book review
- Authors: Knox, Caroline M
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/452322 , vital:75120 , https://hdl.handle.net/10520/EJC32875
- Description: Emerging and re-emerging vector-borne diseases caused by viruses, bacteria, protozoa and other pathogens have increased dramatically throughout the world in recent years. Among the factors that have undoubtedly contributed to this scenario are environmental change, increased international trade and travel, human-induced changes in land use, technical innovations in food processing, microbial adaptation and insecticide resistance. Such diseases pose a serious threat to both human and animal health, and measures for their surveillance and control urgently need to be implemented. In view of the fact that infectious diseases are currently appearing in countries where they did not previously exist or are reappearing after a period of decline, this book is both timely and crucial to our understanding and awareness of this serious problem.
- Full Text:
- Date Issued: 2011
- Authors: Knox, Caroline M
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/452322 , vital:75120 , https://hdl.handle.net/10520/EJC32875
- Description: Emerging and re-emerging vector-borne diseases caused by viruses, bacteria, protozoa and other pathogens have increased dramatically throughout the world in recent years. Among the factors that have undoubtedly contributed to this scenario are environmental change, increased international trade and travel, human-induced changes in land use, technical innovations in food processing, microbial adaptation and insecticide resistance. Such diseases pose a serious threat to both human and animal health, and measures for their surveillance and control urgently need to be implemented. In view of the fact that infectious diseases are currently appearing in countries where they did not previously exist or are reappearing after a period of decline, this book is both timely and crucial to our understanding and awareness of this serious problem.
- Full Text:
- Date Issued: 2011
Theiler’s murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin:
- Mutsvunguma, Lorraine Z, Moetlhoa, Boitumelo, Edkins, Adrienne L, Luke, Garry A, Blatch, Gregory L, Knox, Caroline M
- Authors: Mutsvunguma, Lorraine Z , Moetlhoa, Boitumelo , Edkins, Adrienne L , Luke, Garry A , Blatch, Gregory L , Knox, Caroline M
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165085 , vital:41207 , DOI: 10.1007/s12192-011-0262-x
- Description: Theiler’s murine encephalomyelitis virus (TMEV) is a positive-sense RNA virus belonging to the Cardiovirus genus in the family Picornaviridae. In addition to other host cellular factors and pathways, picornaviruses utilise heat shock proteins (Hsps) to facilitate their propagation in cells. This study investigated the localisation of Hsps 70 and 90 in TMEV-infected BHK-21 cells by indirect immunofluorescence and confocal microscopy. The effect of Hsp90 inhibitors novobiocin (Nov) and geldanamycin (GA) on the development of cytopathic effect (CPE) induced by infection was also examined. Hsp90 staining was uniformly distributed in the cytoplasm of uninfected cells but was found concentrated in the perinuclear region during late infection where it overlapped with the signal for non-structural protein 2C within the viral replication complex.
- Full Text:
- Date Issued: 2011
- Authors: Mutsvunguma, Lorraine Z , Moetlhoa, Boitumelo , Edkins, Adrienne L , Luke, Garry A , Blatch, Gregory L , Knox, Caroline M
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165085 , vital:41207 , DOI: 10.1007/s12192-011-0262-x
- Description: Theiler’s murine encephalomyelitis virus (TMEV) is a positive-sense RNA virus belonging to the Cardiovirus genus in the family Picornaviridae. In addition to other host cellular factors and pathways, picornaviruses utilise heat shock proteins (Hsps) to facilitate their propagation in cells. This study investigated the localisation of Hsps 70 and 90 in TMEV-infected BHK-21 cells by indirect immunofluorescence and confocal microscopy. The effect of Hsp90 inhibitors novobiocin (Nov) and geldanamycin (GA) on the development of cytopathic effect (CPE) induced by infection was also examined. Hsp90 staining was uniformly distributed in the cytoplasm of uninfected cells but was found concentrated in the perinuclear region during late infection where it overlapped with the signal for non-structural protein 2C within the viral replication complex.
- Full Text:
- Date Issued: 2011
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