- Title
- Behavioural activities and chemical composition of fresh leaf essential oil of Plectranthus aegyptiacus from Southwest Nigeria in mice
- Creator
- Akuegbe, Enimeya Dressman
- Creator
- Oyemitan, Idris Ajayi
- Creator
- Oyedeji, Opeoluwa
- Creator
- Ogunlowo, Ifeoluwa Isaac
- Creator
- Miya, Gugulethu Mathew
- Creator
- Oyedeji, Adebola
- Description
- This study determined the chemical composition of essential oil obtained from fresh leaf of Plectranthus aegyptiacus, and evaluated it for novelty-induced behavioural (NIB) and determine its mechanism(s) of action in mice. The oil was hydro-distillated, and analyzed using gas chromatography-mass spectrometry. The effects of the oil (50, 100 and 150 mg/kg; i.p., n=6) on novelty-induced behavioural was assessed using open field test and head dipping on hole board. Probable mechanism(s) were evaluated using antagonists: flumazenil, naloxone and cyproheptadine at 2 mg/kg each, atropine and yohimbine at 5 mg/kg and 1 mg/kg respectively. The LD50 values obtained were 2154 and 490 mg/kg for oral and intraperitoneal routes respectively. The oil (50, 100 and150 mg/kg) significantly (p less 0.05, 0.01 and 0.01) inhibited all NIB and head dips. Flumazenil significantly (p less than 0.05) reversed the effect of the oil on NIB; atropine, naloxone and cyproheptadine significantly (p less than 0.01, 0.01 and 0.001) potentiated inhibitory effect on NIB respectively, while yohimbine showed no significantly effect. The analyzed oil showed 61 compounds, and the major compounds were carvacrol, germacrene-D, p-cymene and [1,1'-Bicyclopentyl]-2,2'-diol. The study concluded that the oil possessed central nervous system depressant activity, which could be mediated mainly through augmentation of GABAergic neurotransmission, while cholinergic-(muscarinic), adrenergic and serotonergic pathways may be involved.
- Date
- 2021-6
- Subject
- Acute toxicity testing
- Subject
- Carvacrol
- Subject
- Essential oil
- Subject
- Behaviour modification
- Subject
- Plectranthus
- Type
- text, article
- Identifier
- http://hdl.handle.net/11260/6506
- Identifier
- vital:46434
- Identifier
- ("https://doi.org/10.30574/gscbps.2021.14.2.0030")
- Format
- computer, online resource, application/pdf, 1 online resource (65-76 pages), pdf
- Publisher
- GSCOnlinePress
- Language
- English
- Relation
- GSC Biological and Pharmaceutical Sciences, GSC Biological and Pharmaceutical Sciences, 2021, 14(02), 064-076., GSC Biological and Pharmaceutical Sciences volume 14 number 02 p.1 Feb 2021 064–076
- Rights
- © 2021 Author(s), GSC Biological and Pharmaceutical Sciences (GSCBPS)., This is an open access article under the CC BY 4.0 license.
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | GSCBPS-2021-0030 (1) - Akuegbe et al EO of Plectranthus.pdf | 1010 KB | Adobe Acrobat PDF | View Details |