Socioeconomic and geographic variations in antenatal care coverage in Angola: further analysis of the 2015 demographic and health survey
- Shibre, Gebretsadik, Zegeye, Betregiorgis, Idriss-Wheeler, Dina, Ahinkorah, Bright Opoku, Oladimeji, Olanrewaju, Yaya, Sanni
- Authors: Shibre, Gebretsadik , Zegeye, Betregiorgis , Idriss-Wheeler, Dina , Ahinkorah, Bright Opoku , Oladimeji, Olanrewaju , Yaya, Sanni
- Date: 2023
- Subjects: Prenatal care , Mothers -- Mortality , Health surveys
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4489 , vital:44125 , https://doi.org/10.1186/s12889-020-09320-1
- Description: In African countries, including Angola, antenatal care (ANC) coverage is suboptimal and maternal mortality is still high due to pregnancy and childbirth-related complications. There is evidence of disparities in the uptake of ANC services, however, little is known about both the socio-economic and geographic-based disparity in the use of ANC services in Angola. The aim of this study was to assess the extent of socio-economic, urban-rural and subnational inequality in ANC coverage in Angola. We analyzed data from the 2015 Angola Demographic and Health Survey (ADHS) using the World Health Organization (WHO) Health Equity Assessment Toolkit (HEAT) software. The analysis consisted of disaggregated ANC coverage rates using four equity stratifiers (economic status, education, residence, and region) and four summary measures (Difference, Population Attributable Risk, Ratio and Population Attributable Fraction). To measure statistical significance, an uncertainty interval (UI) of 95% was constructed around point estimates. The study showed both absolute and relative inequalities in coverage of ANC services in Angola. More specifically, inequality favored women who were rich (D = 54.2, 95% UI; 49.59, 58.70, PAF = 43.5, 95% UI; 40.12, 46.92), educated (PAR = 19.9, 95% UI; 18.14, 21.64, R = 2.14, 95% UI; 1.96, 2.32), living in regions such as Luanda (D = 51.7, 95% UI; 43.56, 59.85, R = 2.64, 95% UI; 2.01, 3.26) and residing in urban dwellings (PAF = 20, 95% UI; 17.70, 22.38, PAR = 12.3, 95% UI; 10.88, 13.75). The uptake of ANC services were lower among poor, uneducated, and rural residents as well as women from the Cuanza Sul region. Government policy makers must consider vulnerable subpopulations when designing needed interventions to improve ANC coverage in Angola to achieve the 2030 Sustainable Development Goal of reducing global maternal mortality ratio to 70 deaths per 100,000 live births.
- Full Text:
- Authors: Shibre, Gebretsadik , Zegeye, Betregiorgis , Idriss-Wheeler, Dina , Ahinkorah, Bright Opoku , Oladimeji, Olanrewaju , Yaya, Sanni
- Date: 2023
- Subjects: Prenatal care , Mothers -- Mortality , Health surveys
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4489 , vital:44125 , https://doi.org/10.1186/s12889-020-09320-1
- Description: In African countries, including Angola, antenatal care (ANC) coverage is suboptimal and maternal mortality is still high due to pregnancy and childbirth-related complications. There is evidence of disparities in the uptake of ANC services, however, little is known about both the socio-economic and geographic-based disparity in the use of ANC services in Angola. The aim of this study was to assess the extent of socio-economic, urban-rural and subnational inequality in ANC coverage in Angola. We analyzed data from the 2015 Angola Demographic and Health Survey (ADHS) using the World Health Organization (WHO) Health Equity Assessment Toolkit (HEAT) software. The analysis consisted of disaggregated ANC coverage rates using four equity stratifiers (economic status, education, residence, and region) and four summary measures (Difference, Population Attributable Risk, Ratio and Population Attributable Fraction). To measure statistical significance, an uncertainty interval (UI) of 95% was constructed around point estimates. The study showed both absolute and relative inequalities in coverage of ANC services in Angola. More specifically, inequality favored women who were rich (D = 54.2, 95% UI; 49.59, 58.70, PAF = 43.5, 95% UI; 40.12, 46.92), educated (PAR = 19.9, 95% UI; 18.14, 21.64, R = 2.14, 95% UI; 1.96, 2.32), living in regions such as Luanda (D = 51.7, 95% UI; 43.56, 59.85, R = 2.64, 95% UI; 2.01, 3.26) and residing in urban dwellings (PAF = 20, 95% UI; 17.70, 22.38, PAR = 12.3, 95% UI; 10.88, 13.75). The uptake of ANC services were lower among poor, uneducated, and rural residents as well as women from the Cuanza Sul region. Government policy makers must consider vulnerable subpopulations when designing needed interventions to improve ANC coverage in Angola to achieve the 2030 Sustainable Development Goal of reducing global maternal mortality ratio to 70 deaths per 100,000 live births.
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Epidemiology, risk factors and molecular analysis of carbapenem-resistant Enterobacteriaceae (CRE) in Mthatha, Eastern Cape, South Africa:
- S.D.Vasaikar, P.Hanise, D.T.Abaver
- Authors: S.D.Vasaikar , P.Hanise , D.T.Abaver
- Date: 2021
- Subjects: Epidemiology Carbapenem-resistant Enterobacteriaceae Mthatha
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3129 , vital:43143 , xlink:href="https://doi.org/10.3390/f10060467"
- Description: Abstract text. Background: The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to global health. Reported outcomes of infections with carbapenem-resistant Enterobacteriaceae (CRE) are poor. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. This study aimed to investigate the resistance genes responsible for CRE in Mthatha and to identify risk factors. Methods and materials: Study design – Prospective cohort study. Study period – 23 April to 27 September 2019. Setting – Eastern Cape province, SA. Study population – All adult and paediatric CRE patients. CRE case definition according to CDC 2018. ID and AST-bioMérieux Vitek 2 system. Detection of the blaOXA-48, blaKPC, blaNDM, and blaVIM by the RESIST-4 OKNV assay (Coris). Patients were interviewed to determine risk factors associated with CRE. Results: Forty-four non-duplicate CRE patients were identified during the study period from microbiology lab at NMAH. Enterobacteriaceae species: K. pneumoniae 22 (61.4%), E. cloacae 10 (22.7%), E. coli 2 (4.5%) and K. oxytoca, P. rettgeri and M. morganii 1 each (4.3%). Adult patient 29 (65.9%0 and paediatric 15 (34.1%). Race: all black patients except one white. CRE genes-blaOXA-48 22 (50%), blaNDM 8 (18.2%), two isolates (4.5%) with both blaOXA and blaNDM. We did not find any blaKPC and blaVIM in our setting and 12 (27.2%) isolates were negative for all OKNV. Outcomes: Demised 18 (40.9%), still admitted in the ward 1 (2.3%), discharged home on basis of clinical grounds 22 (50%) and 3 (6.8%) were transferred back to the district hospitals. HAI in 27 (61.4%) with VAP 8, HABSI 8, CAUTI 5, SSI 3 and CLABSI in 3. Risk factors for CRE acquisition were antibiotic exposure 25 (58.7%), ICU stay 7 (15.9%), received medical care in last 6 months 35 (79.6%) and none travelled outside RSA. HIV positive – 19 (43.2%). Conclusion: In out setting our CRE mortality rate is 40.9%, common CRE genotypes are blaOXA-48 and blaNDM. K. pneumoniae is the most common CRE-producing Enterobacteriaceae and antibiotic exposure is an important risk factor in Mthatha and surrounding areas.
- Full Text:
- Authors: S.D.Vasaikar , P.Hanise , D.T.Abaver
- Date: 2021
- Subjects: Epidemiology Carbapenem-resistant Enterobacteriaceae Mthatha
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3129 , vital:43143 , xlink:href="https://doi.org/10.3390/f10060467"
- Description: Abstract text. Background: The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to global health. Reported outcomes of infections with carbapenem-resistant Enterobacteriaceae (CRE) are poor. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. This study aimed to investigate the resistance genes responsible for CRE in Mthatha and to identify risk factors. Methods and materials: Study design – Prospective cohort study. Study period – 23 April to 27 September 2019. Setting – Eastern Cape province, SA. Study population – All adult and paediatric CRE patients. CRE case definition according to CDC 2018. ID and AST-bioMérieux Vitek 2 system. Detection of the blaOXA-48, blaKPC, blaNDM, and blaVIM by the RESIST-4 OKNV assay (Coris). Patients were interviewed to determine risk factors associated with CRE. Results: Forty-four non-duplicate CRE patients were identified during the study period from microbiology lab at NMAH. Enterobacteriaceae species: K. pneumoniae 22 (61.4%), E. cloacae 10 (22.7%), E. coli 2 (4.5%) and K. oxytoca, P. rettgeri and M. morganii 1 each (4.3%). Adult patient 29 (65.9%0 and paediatric 15 (34.1%). Race: all black patients except one white. CRE genes-blaOXA-48 22 (50%), blaNDM 8 (18.2%), two isolates (4.5%) with both blaOXA and blaNDM. We did not find any blaKPC and blaVIM in our setting and 12 (27.2%) isolates were negative for all OKNV. Outcomes: Demised 18 (40.9%), still admitted in the ward 1 (2.3%), discharged home on basis of clinical grounds 22 (50%) and 3 (6.8%) were transferred back to the district hospitals. HAI in 27 (61.4%) with VAP 8, HABSI 8, CAUTI 5, SSI 3 and CLABSI in 3. Risk factors for CRE acquisition were antibiotic exposure 25 (58.7%), ICU stay 7 (15.9%), received medical care in last 6 months 35 (79.6%) and none travelled outside RSA. HIV positive – 19 (43.2%). Conclusion: In out setting our CRE mortality rate is 40.9%, common CRE genotypes are blaOXA-48 and blaNDM. K. pneumoniae is the most common CRE-producing Enterobacteriaceae and antibiotic exposure is an important risk factor in Mthatha and surrounding areas.
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Sociodemographic inequities associated with participation in leisure-time physical activity in sub-Saharan Africa: an individual participant data meta-analysis
- Longo-Mbenza, Benjamin, Barr, Anna Louise, Partap, Uttara, Young, Elizabeth H, Agoudavi, Kokou, Balde, Naby, Kagaruki, Gibson B, Mayige, Mary T, Mutungi, Gerald, Mwalim, Omar, Wesseh, Chea S, Bahendeka, Silver K, Guwatudde, David, Jørgensen, Jutta M Adelin, Bovet, Pascal, Motala, Ayesha A, Sandhu, Manjinder S
- Authors: Longo-Mbenza, Benjamin , Barr, Anna Louise , Partap, Uttara , Young, Elizabeth H , Agoudavi, Kokou , Balde, Naby , Kagaruki, Gibson B , Mayige, Mary T , Mutungi, Gerald , Mwalim, Omar , Wesseh, Chea S , Bahendeka, Silver K , Guwatudde, David , Jørgensen, Jutta M Adelin , Bovet, Pascal , Motala, Ayesha A , Sandhu, Manjinder S
- Date: 2020-06-15
- Subjects: Recreation. Use of leisure time , Occupational therapy , Health surveys
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3378 , vital:43337 , https://doi.org/10.1186/s12889-020-08987-w
- Description: Leisure-time physical activity (LTPA) is an important contributor to total physical activity and the focus of many interventions promoting activity in high-income populations. Little is known about LTPA in subSaharan Africa (SSA), and with expected declines in physical activity due to rapid urbanisation and lifestyle changes we aimed to assess the sociodemographic differences in the prevalence of LTPA in the adult populations of this region to identify potential barriers for equitable participation. A two-step individual participant data meta-analysis was conducted using data collected in SSA through 10 population health surveys that included the Global Physical Activity Questionnaire. For each sociodemographic characteristic, the pooled adjusted prevalence and risk ratios (RRs) for participation in LTPA were calculated using the random effects method. Between-study heterogeneity was explored through meta-regression analyses and tests for interaction. Across the 10 populations (N = 26,022), 18.9% (95%CI: 14.3, 24.1; I2 = 99.0%) of adults (≥ 18 years) participated in LTPA. Men were more likely to participate in LTPA compared with women (RR for women: 0.43; 95%CI: 0.32, 0.60; P less than 0.001; I2 = 97.5%), while age was inversely associated with participation. Higher levels of education were associated with increased LTPA participation (RR: 1.30; 95%CI: 1.09, 1.55; P = 0.004; I2 = 98.1%), with those living in rural areas or self-employed less likely to participate in LTPA. These associations remained after adjusting for time spent physically active at work or through active travel. In these populations, participation in LTPA was low, and strongly associated with sex, age, education, self-employment and urban residence. Identifying the potential barriers that reduce participation in these groups is necessary to enable equitable access to the health and social benefits associated with LTPA.
- Full Text:
- Authors: Longo-Mbenza, Benjamin , Barr, Anna Louise , Partap, Uttara , Young, Elizabeth H , Agoudavi, Kokou , Balde, Naby , Kagaruki, Gibson B , Mayige, Mary T , Mutungi, Gerald , Mwalim, Omar , Wesseh, Chea S , Bahendeka, Silver K , Guwatudde, David , Jørgensen, Jutta M Adelin , Bovet, Pascal , Motala, Ayesha A , Sandhu, Manjinder S
- Date: 2020-06-15
- Subjects: Recreation. Use of leisure time , Occupational therapy , Health surveys
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3378 , vital:43337 , https://doi.org/10.1186/s12889-020-08987-w
- Description: Leisure-time physical activity (LTPA) is an important contributor to total physical activity and the focus of many interventions promoting activity in high-income populations. Little is known about LTPA in subSaharan Africa (SSA), and with expected declines in physical activity due to rapid urbanisation and lifestyle changes we aimed to assess the sociodemographic differences in the prevalence of LTPA in the adult populations of this region to identify potential barriers for equitable participation. A two-step individual participant data meta-analysis was conducted using data collected in SSA through 10 population health surveys that included the Global Physical Activity Questionnaire. For each sociodemographic characteristic, the pooled adjusted prevalence and risk ratios (RRs) for participation in LTPA were calculated using the random effects method. Between-study heterogeneity was explored through meta-regression analyses and tests for interaction. Across the 10 populations (N = 26,022), 18.9% (95%CI: 14.3, 24.1; I2 = 99.0%) of adults (≥ 18 years) participated in LTPA. Men were more likely to participate in LTPA compared with women (RR for women: 0.43; 95%CI: 0.32, 0.60; P less than 0.001; I2 = 97.5%), while age was inversely associated with participation. Higher levels of education were associated with increased LTPA participation (RR: 1.30; 95%CI: 1.09, 1.55; P = 0.004; I2 = 98.1%), with those living in rural areas or self-employed less likely to participate in LTPA. These associations remained after adjusting for time spent physically active at work or through active travel. In these populations, participation in LTPA was low, and strongly associated with sex, age, education, self-employment and urban residence. Identifying the potential barriers that reduce participation in these groups is necessary to enable equitable access to the health and social benefits associated with LTPA.
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BTC price volatility: fundamentals versus information
- Gbadebo, Adedeji Daniel, Adekunle, Ahmed Oluwatobi, Adebayo-Oke Abdulrauf Lukman, Adedokun, Wole, Akande, Joseph
- Authors: Gbadebo, Adedeji Daniel , Adekunle, Ahmed Oluwatobi , Adebayo-Oke Abdulrauf Lukman , Adedokun, Wole , Akande, Joseph
- Date: 2020
- Subjects: Bitcoin price volatility , Bitcoin market fundamentals , Autoregressive Distributed Lag (ARDL)
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/6978 , vital:52630 , https://doi.org/10.1080/23311975.2021.1984624
- Description: This paper offers a plausible response to “what explains the sporadic volatility in the price of Bitcoin?” We hypothesized that market “fundamentals” and “information demands” are key drivers of Bitcoin’s unpredictable price fluctuation. We adopt the transfer-function [Autoregressive Distributed Lag, ARDL] model and its Bounds testing approach to verify how the volatility of the price of Bitcoin responds to its transaction volume, cryptocurrency market capitalisation, world market equity index and Google search. We found the existence of long-run cointegration relation and observed that all the variables except the equity index positively explain the volatility of Bitcoin price. The result established evidence that market fundamentals drive erratic swing in Bitcoin price than information.
- Full Text:
- Authors: Gbadebo, Adedeji Daniel , Adekunle, Ahmed Oluwatobi , Adebayo-Oke Abdulrauf Lukman , Adedokun, Wole , Akande, Joseph
- Date: 2020
- Subjects: Bitcoin price volatility , Bitcoin market fundamentals , Autoregressive Distributed Lag (ARDL)
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/6978 , vital:52630 , https://doi.org/10.1080/23311975.2021.1984624
- Description: This paper offers a plausible response to “what explains the sporadic volatility in the price of Bitcoin?” We hypothesized that market “fundamentals” and “information demands” are key drivers of Bitcoin’s unpredictable price fluctuation. We adopt the transfer-function [Autoregressive Distributed Lag, ARDL] model and its Bounds testing approach to verify how the volatility of the price of Bitcoin responds to its transaction volume, cryptocurrency market capitalisation, world market equity index and Google search. We found the existence of long-run cointegration relation and observed that all the variables except the equity index positively explain the volatility of Bitcoin price. The result established evidence that market fundamentals drive erratic swing in Bitcoin price than information.
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Comprehensive data on the mechanical properties and biodegradation profile of polylactide composites developed for hard tissue repairs
- Aworinde, Abraham K, Adeosun, Samson O, Oyawale, Festus A, Emagbetere, Eyere, Ishola, Felix A, Olatunji, Obafemi, Akinlab, Stephen, Oyedepo, Sunday O, Ajayi, Oluseyi O, Akinlabi, Esther T
- Authors: Aworinde, Abraham K , Adeosun, Samson O , Oyawale, Festus A , Emagbetere, Eyere , Ishola, Felix A , Olatunji, Obafemi , Akinlab, Stephen , Oyedepo, Sunday O , Ajayi, Oluseyi O , Akinlabi, Esther T
- Date: 2020
- Subjects: Regeneration (Biology) , Vickers microhardness , Melt-blending technique
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3149 , vital:43158 , https://doi.org/10.1016/j.dib.2020.106107
- Description: Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.
- Full Text:
- Authors: Aworinde, Abraham K , Adeosun, Samson O , Oyawale, Festus A , Emagbetere, Eyere , Ishola, Felix A , Olatunji, Obafemi , Akinlab, Stephen , Oyedepo, Sunday O , Ajayi, Oluseyi O , Akinlabi, Esther T
- Date: 2020
- Subjects: Regeneration (Biology) , Vickers microhardness , Melt-blending technique
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3149 , vital:43158 , https://doi.org/10.1016/j.dib.2020.106107
- Description: Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.
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Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
- Masilela, Charity, Pearce, Brendon, Ongole, Joven Jebio, Adeniyi, Oladele Vincent, Benjeddou, Mongi
- Authors: Masilela, Charity , Pearce, Brendon , Ongole, Joven Jebio , Adeniyi, Oladele Vincent , Benjeddou, Mongi
- Date: 2020
- Subjects: Blood pressure control , Dyslipidaemia , Uncontrolled hypertension
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/4481 , vital:44124 , https://doi.org/10.1186/s12889-020-09174-7
- Description: Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the developing countries. Therefore, this study comprehensively examined the prevalence and factors associated with uncontrolled hypertension in individuals receiving care at the primary healthcare facilities in the rural areas of Mkhondo Municipality in the Mpumalanga Province, South Africa. Methods: In this cross-sectional study, 329 individuals attending care for hypertension were recruited from January 2019 to June 2019 at three primary healthcare centres, namely, Piet Retief hospital, Mkhondo town clinic and Thandukukhanya community health centre. Uncontrolled hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg in accordance with the South African Hypertension Society guideline (2014). Multiple logistic regression (Forward LR method) analysis was used to identify the significant determinants of uncontrolled hypertension. Results: The majority of the participants were 55 years old and above (69.0%), Zulus (81.2%), non-smokers (84.19%) and had been diagnosed with hypertension for more than a year prior to the study (72.64%). The overall prevalence of uncontrolled hypertension was 56.83% (n = 187) with no significant difference between sexes, 57.38% male versus 56.88% female, respectively. In the multiple logistic regression model analysis after adjusting for confounding variables, obesity (AOR = 2.90; 95% CI 1.66–5.05), physical activity (AOR = 4.79; 95% CI 2.15–10.65) and HDL-C (AOR = 5.66; 95% CI 3.33–9.60) were the significant and independent determinants of uncontrolled hypertension in the cohort. Conclusion: The high prevalence of uncontrolled hypertension in the study setting can be largely attributed to obesity, physical activity and dyslipidaemia. Treatment will require the collaborative efforts of individuals, clinicians and health authorities. All these determinants should be addressed decisively so as to achieve the treatment blood pressure targets in the study population.
- Full Text:
- Authors: Masilela, Charity , Pearce, Brendon , Ongole, Joven Jebio , Adeniyi, Oladele Vincent , Benjeddou, Mongi
- Date: 2020
- Subjects: Blood pressure control , Dyslipidaemia , Uncontrolled hypertension
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/4481 , vital:44124 , https://doi.org/10.1186/s12889-020-09174-7
- Description: Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the developing countries. Therefore, this study comprehensively examined the prevalence and factors associated with uncontrolled hypertension in individuals receiving care at the primary healthcare facilities in the rural areas of Mkhondo Municipality in the Mpumalanga Province, South Africa. Methods: In this cross-sectional study, 329 individuals attending care for hypertension were recruited from January 2019 to June 2019 at three primary healthcare centres, namely, Piet Retief hospital, Mkhondo town clinic and Thandukukhanya community health centre. Uncontrolled hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg in accordance with the South African Hypertension Society guideline (2014). Multiple logistic regression (Forward LR method) analysis was used to identify the significant determinants of uncontrolled hypertension. Results: The majority of the participants were 55 years old and above (69.0%), Zulus (81.2%), non-smokers (84.19%) and had been diagnosed with hypertension for more than a year prior to the study (72.64%). The overall prevalence of uncontrolled hypertension was 56.83% (n = 187) with no significant difference between sexes, 57.38% male versus 56.88% female, respectively. In the multiple logistic regression model analysis after adjusting for confounding variables, obesity (AOR = 2.90; 95% CI 1.66–5.05), physical activity (AOR = 4.79; 95% CI 2.15–10.65) and HDL-C (AOR = 5.66; 95% CI 3.33–9.60) were the significant and independent determinants of uncontrolled hypertension in the cohort. Conclusion: The high prevalence of uncontrolled hypertension in the study setting can be largely attributed to obesity, physical activity and dyslipidaemia. Treatment will require the collaborative efforts of individuals, clinicians and health authorities. All these determinants should be addressed decisively so as to achieve the treatment blood pressure targets in the study population.
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Data on microhardness and structural analysis of friction stir spot welded lap joints of AA5083-H116
- Esther T. Akinlabi, Ayuba S. Osinubi b, Nkosinathi Madushele b, Stephen A. Akinlabi c, Omolayo M. Ikumapayi d,∗
- Authors: Esther T. Akinlabi , Ayuba S. Osinubi b , Nkosinathi Madushele b , Stephen A. Akinlabi c , Omolayo M. Ikumapayi d,∗
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3260 , vital:43286 , https://www.sciencedirect.com/science/article/pii/S2352340920314669
- Description: Friction stir spot welding (FSSW) was established to compete reasonably with the reverting, bolting, adhesive bonding as well as resistance spot welding (RSW) which have been used in the past for lap joining in automobile, aerospace, marine, railways, defence and shipbuilding industries. The use of these ancient and conventional joining techniques had led to increasing material cost, installation labour, and additional weight in the aircraft, shipbuilding, and other areas of applications. All these are disadvantages that can be overcome using FSSW. This research work carried out friction stir spot welding on 5058-H116 aluminium alloy by employing rotational speed in the step of 300 rpm ranges from 600 rpm to 1200 rpm with a no travel speed. It was noted that the dwell times were in the step of 5 s varying from 5 s to 15 s while the tool plunge rate was maintained at 30 mm/min. In this dataset, a cylindrical tapered rotating H13 Hot-working steel tool was used with a probe length of 5 mm and probe diameter of 6 mm, it has a shoulder diameter of 18 mm. The tool penetration depth (plunge) was maintained at 0.2 mm and the tool tilt angle at 2°. Structural integrity was car-ried out using Rigaku ultima IV multifunctional X-ray diffractometer (XRD) with a scan voltage of 40 kV and scan current of 30 mA. This was used to determine crystallite sizes, peak intensity, d-spacing, full width at half maximum intensity (FWHM) of the diffraction peak. TH713 digital microhardness equipment with diamond indenter was used for microhardness data acquisition following ASTM E92–82 standard test. The average Vickers hardness data values at different zones of the spot-welds were captured and presented.
- Full Text:
Data on microhardness and structural analysis of friction stir spot welded lap joints of AA5083-H116
- Authors: Esther T. Akinlabi , Ayuba S. Osinubi b , Nkosinathi Madushele b , Stephen A. Akinlabi c , Omolayo M. Ikumapayi d,∗
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3260 , vital:43286 , https://www.sciencedirect.com/science/article/pii/S2352340920314669
- Description: Friction stir spot welding (FSSW) was established to compete reasonably with the reverting, bolting, adhesive bonding as well as resistance spot welding (RSW) which have been used in the past for lap joining in automobile, aerospace, marine, railways, defence and shipbuilding industries. The use of these ancient and conventional joining techniques had led to increasing material cost, installation labour, and additional weight in the aircraft, shipbuilding, and other areas of applications. All these are disadvantages that can be overcome using FSSW. This research work carried out friction stir spot welding on 5058-H116 aluminium alloy by employing rotational speed in the step of 300 rpm ranges from 600 rpm to 1200 rpm with a no travel speed. It was noted that the dwell times were in the step of 5 s varying from 5 s to 15 s while the tool plunge rate was maintained at 30 mm/min. In this dataset, a cylindrical tapered rotating H13 Hot-working steel tool was used with a probe length of 5 mm and probe diameter of 6 mm, it has a shoulder diameter of 18 mm. The tool penetration depth (plunge) was maintained at 0.2 mm and the tool tilt angle at 2°. Structural integrity was car-ried out using Rigaku ultima IV multifunctional X-ray diffractometer (XRD) with a scan voltage of 40 kV and scan current of 30 mA. This was used to determine crystallite sizes, peak intensity, d-spacing, full width at half maximum intensity (FWHM) of the diffraction peak. TH713 digital microhardness equipment with diamond indenter was used for microhardness data acquisition following ASTM E92–82 standard test. The average Vickers hardness data values at different zones of the spot-welds were captured and presented.
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Dataset and ANN model prediction of performance of graphene nanolubricant with R600a in domestic refrigerator system
- Taiwo, Babarinde, Stephen, Akinlabi, Daniel Makundwaneyi, Madyira, Ekundayo, Funmilayo M, Paul Adeola, Adedeji
- Authors: Taiwo, Babarinde , Stephen, Akinlabi , Daniel Makundwaneyi, Madyira , Ekundayo, Funmilayo M , Paul Adeola, Adedeji
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3139 , vital:43150 , (https://www.sciencedirect.com/science/article/pii/S2352340920309926)
- Description: This work evaluated the steady state performance of R600a in the base lubricant and graphene nanolubricant. The measuring instruments required and their uncertainties were provided, step by step method and procedures for preparation of graphene nanolubricant concentration and substituting it with the base lubricant in domestic refrigerator system are described. The system temperatures data was captured at the inlet and outlet of the system components. Also, the pressures data was recorded at the compressor inlet and outlet. The data was recorded for 3 h at 30 min interval at an ambient temperature of 27 °C. The experimental dataset, Artificial Neural Network (ANN) training and testing dataset are provided. The artificial intelligence approach of ANN model to predict the performance of graphene nanolubricant in domestic refrigerator is explained. Also, the ANN model prediction statistical performance metrics such as Root Mean Square Error (RMSE) and Mean Absolute Deviation (MAD), Mean Absolute Percentage Error (MAPE) and coefficient of determination (R2) are also provided. The data is useful to researchers in the field of refrigeration and energy efficiency materials, for replacing nanolubricant with the base lubricant in refrigerator systems. The data can be reuse for simulation and modelling vapour compression energy system.
- Full Text:
- Authors: Taiwo, Babarinde , Stephen, Akinlabi , Daniel Makundwaneyi, Madyira , Ekundayo, Funmilayo M , Paul Adeola, Adedeji
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3139 , vital:43150 , (https://www.sciencedirect.com/science/article/pii/S2352340920309926)
- Description: This work evaluated the steady state performance of R600a in the base lubricant and graphene nanolubricant. The measuring instruments required and their uncertainties were provided, step by step method and procedures for preparation of graphene nanolubricant concentration and substituting it with the base lubricant in domestic refrigerator system are described. The system temperatures data was captured at the inlet and outlet of the system components. Also, the pressures data was recorded at the compressor inlet and outlet. The data was recorded for 3 h at 30 min interval at an ambient temperature of 27 °C. The experimental dataset, Artificial Neural Network (ANN) training and testing dataset are provided. The artificial intelligence approach of ANN model to predict the performance of graphene nanolubricant in domestic refrigerator is explained. Also, the ANN model prediction statistical performance metrics such as Root Mean Square Error (RMSE) and Mean Absolute Deviation (MAD), Mean Absolute Percentage Error (MAPE) and coefficient of determination (R2) are also provided. The data is useful to researchers in the field of refrigeration and energy efficiency materials, for replacing nanolubricant with the base lubricant in refrigerator systems. The data can be reuse for simulation and modelling vapour compression energy system.
- Full Text:
Dataset of experimental and adaptive neuro-fuzzy inference system (ANFIS) model prediction of R600a/MWCNT nanolubricant in a vapour compression system
- Babarinde, T O, Akinlabi, S A, Madyira, D M, Ekundayo, F M, Adedeji, P A
- Authors: Babarinde, T O , Akinlabi, S A , Madyira, D M , Ekundayo, F M , Adedeji, P A
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3248 , vital:43283 , https://www.sciencedirect.com/science/article/pii/S2352340920312105
- Description: This research paper assessed the performance of R600a with the base lubricant and Multi-walled Carbon Nanotube (MWCNT) nanolubricant at steady state. It describes the instruments required for measurement of the data parameter and its uncertainties, steps involved in preparing and replacing the MWCNT nanolubricant concentration with base lubricant in vapour compression refrigeration. The system’s temperature data was collected at the components inlets and outlets. Pressure data was also registered at the compressor outlet and inlet. The data was captured at 27 °C ambient temperature at an interval of 30 min for 300 min. The experiment includes the experimental data collection, Adaptive Neuro-Fuzzy Inference System (ANFIS) training and testing dataset. The use of ANFIS model is explained in predicting the efficiency of MWCNT nanolubricant in a vapour compression refrigerator system. The ANFIS model also provides statistical output measures such as Root Mean Square Error (RMSE) and Mean Absolute Deviation (MAD), Mean Absolute Percentage Error (MAPE), and determination coefficient (R2). The data is useful and important for replacing MWCNT nanolubricant with base lubricant in a vapour compression refrigeration system for researchers in the specialisation of energy-efficient materials in refrigeration. The data present can be reused for vapour compression refrigeration systems simulation and modelling.
- Full Text:
- Authors: Babarinde, T O , Akinlabi, S A , Madyira, D M , Ekundayo, F M , Adedeji, P A
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3248 , vital:43283 , https://www.sciencedirect.com/science/article/pii/S2352340920312105
- Description: This research paper assessed the performance of R600a with the base lubricant and Multi-walled Carbon Nanotube (MWCNT) nanolubricant at steady state. It describes the instruments required for measurement of the data parameter and its uncertainties, steps involved in preparing and replacing the MWCNT nanolubricant concentration with base lubricant in vapour compression refrigeration. The system’s temperature data was collected at the components inlets and outlets. Pressure data was also registered at the compressor outlet and inlet. The data was captured at 27 °C ambient temperature at an interval of 30 min for 300 min. The experiment includes the experimental data collection, Adaptive Neuro-Fuzzy Inference System (ANFIS) training and testing dataset. The use of ANFIS model is explained in predicting the efficiency of MWCNT nanolubricant in a vapour compression refrigerator system. The ANFIS model also provides statistical output measures such as Root Mean Square Error (RMSE) and Mean Absolute Deviation (MAD), Mean Absolute Percentage Error (MAPE), and determination coefficient (R2). The data is useful and important for replacing MWCNT nanolubricant with base lubricant in a vapour compression refrigeration system for researchers in the specialisation of energy-efficient materials in refrigeration. The data present can be reused for vapour compression refrigeration systems simulation and modelling.
- Full Text:
Essential medicine selection during the COVID-19 pandemic: Enabling access in uncharted territory
- Authors: A G Parrish
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3364 , vital:43319 , http://www.samj.org.za/index.php/samj/article/view/13086
- Description: The COVID-19 pandemic requires urgent decisions regarding treatment policy in the face of rapidly evolving evidence. In response, the South African Essential Medicines List Committee established a subcommittee to systematically review and appraise emerging evidence, within very short timelines, in order to inform the National Department of Health COVID-19 treatment guidelines. To date, the subcommittee has reviewed 14 potential treatments, and made recommendations based on local context, feasibility, resource requirements and equity. Here we describe the rapid review and evidence-to-decision process, using remdesivir and dexamethasone as examples. Our experience is that conducting rapid reviews is a practical and efficient way to address medicine policy questions under pandemic conditions.
- Full Text:
- Authors: A G Parrish
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3364 , vital:43319 , http://www.samj.org.za/index.php/samj/article/view/13086
- Description: The COVID-19 pandemic requires urgent decisions regarding treatment policy in the face of rapidly evolving evidence. In response, the South African Essential Medicines List Committee established a subcommittee to systematically review and appraise emerging evidence, within very short timelines, in order to inform the National Department of Health COVID-19 treatment guidelines. To date, the subcommittee has reviewed 14 potential treatments, and made recommendations based on local context, feasibility, resource requirements and equity. Here we describe the rapid review and evidence-to-decision process, using remdesivir and dexamethasone as examples. Our experience is that conducting rapid reviews is a practical and efficient way to address medicine policy questions under pandemic conditions.
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Events as catalyst to atact tourists to destinations: Spectator perceptions of the social impact of events in East London: A study of Spec-Savers Ironman South Africa 70.3 in Buffalo City
- Authors: Mxunyelwa, Siayabonga
- Date: 2020
- Language: English
- Type: Conference Proceeding
- Identifier: http://hdl.handle.net/11260/10868 , vital:75300
- Description: In recent years, globally events have shown rapid growth as types of attractions within destinations with such events creating a favourable image of a destination, expanding the traditional tourist season, spreading tourist demand evenly through an area and attracting foreign and domestic visitors. As far as South Africa is concerned attracting influx of tourists is the problem in the event sport tourism industry The objective of this study is to address this gap and to evaluate the social impact perceptions of event tourism spectators. The research design for the proposed study primarily involved exploratory and descriptive research. The target-sampling frame was the event tourism spectators at the Spec-Savers Ironman South Africa 70.3 Triathlon event held in East London. The findings suggest that the opportunity to meet new people, attend a major event and enhancing event tourism destination were deemed positive social impacts. Conversely, the study suggested that littering and social inequalities (exclusionary) are negative social impacts. The results in this study have produced a foundation that events management practitioners, event tourism planners, policy makers, decision makers, researchers and academics can utilise in planning for future events that are socially sustainable in a developing economy context such as South Africa.
- Full Text: false
- Authors: Mxunyelwa, Siayabonga
- Date: 2020
- Language: English
- Type: Conference Proceeding
- Identifier: http://hdl.handle.net/11260/10868 , vital:75300
- Description: In recent years, globally events have shown rapid growth as types of attractions within destinations with such events creating a favourable image of a destination, expanding the traditional tourist season, spreading tourist demand evenly through an area and attracting foreign and domestic visitors. As far as South Africa is concerned attracting influx of tourists is the problem in the event sport tourism industry The objective of this study is to address this gap and to evaluate the social impact perceptions of event tourism spectators. The research design for the proposed study primarily involved exploratory and descriptive research. The target-sampling frame was the event tourism spectators at the Spec-Savers Ironman South Africa 70.3 Triathlon event held in East London. The findings suggest that the opportunity to meet new people, attend a major event and enhancing event tourism destination were deemed positive social impacts. Conversely, the study suggested that littering and social inequalities (exclusionary) are negative social impacts. The results in this study have produced a foundation that events management practitioners, event tourism planners, policy makers, decision makers, researchers and academics can utilise in planning for future events that are socially sustainable in a developing economy context such as South Africa.
- Full Text: false
Events tourism as a conduit to promote underdeveloped tourist destinations, with specific reference to the Mooiplaas Homecoming Music Event in East London, South Africa
- Mxunyelwa, Siyabonga, Kilani, Khuselwa Busisiwe
- Authors: Mxunyelwa, Siyabonga , Kilani, Khuselwa Busisiwe
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/1958 , vital:39809 , https://www.ajhtl.com/uploads/7/1/6/3/7163688/article_9_vol_9_2__2020_wsu.pdf
- Description: Events tourism has demonstrated growth over the years, and has been used as a tool to boost local economies. Hosting such events creates benefits, these include the boost in the local economy, improvement of infrastructure on destinations and job creation. The purpose of this paper was to investigate how events tourism could be utilised as a conduit to promote underdeveloped tourist destinations in Mooiplaas. Secondary data sources were consulted to understand the role of events tourism in the local community of Mooiplaas. This paper utilised a survey questionnaire to collect data. The simple random sampling method was utilised to select the respondents. The findings indicate that 70% of the respondents agreed that they are consulted about the events that promote their community. Furthermore, the findings elucidates that 82% of the respondents concur that events can potentially create entrepreneurial opportunities. These findings contribute significantly in developing the local economic strategies of the municipalities in underdeveloped regions. As such it is recommended that events are planned in a coherent, systematic manner in order to achieve local economic development objectives. Furthermore, the paper provided a foundation on how to plan, organise, lead and control events that can potentially unearth tourism demand particularly in developing tourist destinations. Moreover, it is hoped that the paper will serve as the basis to plan future events in the context of regions such as Mooiplaas that are still engulfed with developmental challenges, these contribute to triple threat of unemployed, poverty and inequality.
- Full Text:
- Authors: Mxunyelwa, Siyabonga , Kilani, Khuselwa Busisiwe
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/1958 , vital:39809 , https://www.ajhtl.com/uploads/7/1/6/3/7163688/article_9_vol_9_2__2020_wsu.pdf
- Description: Events tourism has demonstrated growth over the years, and has been used as a tool to boost local economies. Hosting such events creates benefits, these include the boost in the local economy, improvement of infrastructure on destinations and job creation. The purpose of this paper was to investigate how events tourism could be utilised as a conduit to promote underdeveloped tourist destinations in Mooiplaas. Secondary data sources were consulted to understand the role of events tourism in the local community of Mooiplaas. This paper utilised a survey questionnaire to collect data. The simple random sampling method was utilised to select the respondents. The findings indicate that 70% of the respondents agreed that they are consulted about the events that promote their community. Furthermore, the findings elucidates that 82% of the respondents concur that events can potentially create entrepreneurial opportunities. These findings contribute significantly in developing the local economic strategies of the municipalities in underdeveloped regions. As such it is recommended that events are planned in a coherent, systematic manner in order to achieve local economic development objectives. Furthermore, the paper provided a foundation on how to plan, organise, lead and control events that can potentially unearth tourism demand particularly in developing tourist destinations. Moreover, it is hoped that the paper will serve as the basis to plan future events in the context of regions such as Mooiplaas that are still engulfed with developmental challenges, these contribute to triple threat of unemployed, poverty and inequality.
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Genetics of schizophrenia in the South African Xhosa
- Gulsuner, S, Stein, D J, Susser, E S, Sibeko, G, Pretorius, A, Walsh, T, Majara, L, Mndini, M M, Mqulwana, S G, Ntola, O A, Casadei, S, Zingela, Zukiswa, Nagdee, M, Ramesar, R S, King, M-C, McClellan, J M, Ngqengelele, L L, Korchina, V, van der Merwe, C, Malan, M, Fader, K M, Feng, M, Willoughby, E, Munzi, D, Andrews, H F, Gur, R C, Gibbs, R A
- Authors: Gulsuner, S , Stein, D J , Susser, E S , Sibeko, G , Pretorius, A , Walsh, T , Majara, L , Mndini, M M , Mqulwana, S G , Ntola, O A , Casadei, S , Zingela, Zukiswa , Nagdee, M , Ramesar, R S , King, M-C , McClellan, J M , Ngqengelele, L L , Korchina, V , van der Merwe, C , Malan, M , Fader, K M , Feng, M , Willoughby, E , Munzi, D , Andrews, H F , Gur, R C , Gibbs, R A
- Date: 2020
- Subjects: Schizophrenia -- Diagnosis -- Cross-cultural studies , Medical genetics , Xhosa (African people)
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4217 , vital:44044 , https://doi.org/10.1126/science.aay8833
- Description: Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.
- Full Text:
- Authors: Gulsuner, S , Stein, D J , Susser, E S , Sibeko, G , Pretorius, A , Walsh, T , Majara, L , Mndini, M M , Mqulwana, S G , Ntola, O A , Casadei, S , Zingela, Zukiswa , Nagdee, M , Ramesar, R S , King, M-C , McClellan, J M , Ngqengelele, L L , Korchina, V , van der Merwe, C , Malan, M , Fader, K M , Feng, M , Willoughby, E , Munzi, D , Andrews, H F , Gur, R C , Gibbs, R A
- Date: 2020
- Subjects: Schizophrenia -- Diagnosis -- Cross-cultural studies , Medical genetics , Xhosa (African people)
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4217 , vital:44044 , https://doi.org/10.1126/science.aay8833
- Description: Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.
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Intersection of race, gender and class in the interventional life-writings of four selected South African authors
- Ndlovu, Siphatisiwe Patricia
- Authors: Ndlovu, Siphatisiwe Patricia
- Date: 2020
- Subjects: Post-apartheid era -- South Africa , Interventional writing , Fred Khumalo , Malaika wa Azania , Khaya Dlanga , Tumi Morake
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/11260/3414 , vital:43345
- Description: The interventional life writings of second generation life writers (young, black, middleclass South Africans) in post-apartheid South Africa have not attracted much academic debate in spite of the burgeoning of such writings recently. The intersection of race, class and gender in post-apartheid South Africa remains a problem and a rich site of research, hence this research’s reading of four selected life writings by young, black, middle-class South Africans living in post-apartheid South Africa: Fred Khumalo’s Touch My Blood: The Early Years (2006), Malaika Wa Azania’s Memoires of a Born Free: Reflections on the Rainbow Nation (2014), Khaya Dlanga’s To Quote Myself (2015) and Tumi Morake’s And Then Mama Said… Words That Set My Life Alight (2018). Using the intersectional approach, the study explores the lives narrated by second generation South Africans, in a manner similar to the grand narratives because of their historical and social context. The study focalises life/self-writers who have experienced post-apartheid trauma of being racialized, gendered and classed in a democratic country. This is a shift from the staple analysis of lives of political struggle against apartheid, narrated by historical legends such as Nelson Mandela. The study then, by focusing on ‘small voices’ closes a critical gap created by over-attention paid to grand narratives in South African life writing. Self-narrations by young, black, middle-class South Africans emerge not only as a way of narrating history but also as a means of making history. Through the deployment of the intersectional approach (the interconnectedness of inequalities) to analyse the systems of oppression associated with democratic South Africa, the four selected interventional life writers reveal how their experiences and identities are an outcome of constantly renegotiating power relations. , Thesis (MA) -- Faculty of Humanities, Social Sciences and Law, 2020
- Full Text:
- Authors: Ndlovu, Siphatisiwe Patricia
- Date: 2020
- Subjects: Post-apartheid era -- South Africa , Interventional writing , Fred Khumalo , Malaika wa Azania , Khaya Dlanga , Tumi Morake
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/11260/3414 , vital:43345
- Description: The interventional life writings of second generation life writers (young, black, middleclass South Africans) in post-apartheid South Africa have not attracted much academic debate in spite of the burgeoning of such writings recently. The intersection of race, class and gender in post-apartheid South Africa remains a problem and a rich site of research, hence this research’s reading of four selected life writings by young, black, middle-class South Africans living in post-apartheid South Africa: Fred Khumalo’s Touch My Blood: The Early Years (2006), Malaika Wa Azania’s Memoires of a Born Free: Reflections on the Rainbow Nation (2014), Khaya Dlanga’s To Quote Myself (2015) and Tumi Morake’s And Then Mama Said… Words That Set My Life Alight (2018). Using the intersectional approach, the study explores the lives narrated by second generation South Africans, in a manner similar to the grand narratives because of their historical and social context. The study focalises life/self-writers who have experienced post-apartheid trauma of being racialized, gendered and classed in a democratic country. This is a shift from the staple analysis of lives of political struggle against apartheid, narrated by historical legends such as Nelson Mandela. The study then, by focusing on ‘small voices’ closes a critical gap created by over-attention paid to grand narratives in South African life writing. Self-narrations by young, black, middle-class South Africans emerge not only as a way of narrating history but also as a means of making history. Through the deployment of the intersectional approach (the interconnectedness of inequalities) to analyse the systems of oppression associated with democratic South Africa, the four selected interventional life writers reveal how their experiences and identities are an outcome of constantly renegotiating power relations. , Thesis (MA) -- Faculty of Humanities, Social Sciences and Law, 2020
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Patient acceptance of HIV testing services in rural emergency departments in South Africa
- Aditi Rao, Caitlin Kennedy, Pamela Mda, Thomas C. Quinn, David Stead, Bhakti Hansoti
- Authors: Aditi Rao , Caitlin Kennedy , Pamela Mda , Thomas C. Quinn , David Stead , Bhakti Hansoti
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3270 , vital:43287 , https://doi.org/10.4102/sajhivmed.v21i1.1105
- Description: Background: South Africa faces the highest burden of HIV infection globally. The National Strategic Plan on HIV recommends provider-initiated HIV counselling and testing (HCT) in all healthcare facilities. However, HIV continues to overwhelm the healthcare system. Emergency department (ED)-based HCT could address unmet testing needs. Objectives: This study examines the reasons for accepting or declining HCT in South African EDs to inform the development of HCT implementation strategies. Method: We conducted a prospective observational study in two rural EDs, from June to September 2017. Patients presenting to the ED were systematically approached and offered a point-of-care test in accordance with national guidelines. Patients demographics, presenting compaint, medical history and reasons for accepting/declining testing, were recorded. A pooled analysis is presented. Results: Across sites, 2074 adult, non-critical patients in the ED were approached; 1880 were enrolled in the study. Of those enrolled, 19.7% had a previously known positive diagnosis, and 80.3% were unaware of their HIV status. Of those unaware, 90% patients accepted and 10% declined testing. The primary reasons for declining testing were ‘does not want to know status’ (37.6%), ‘in too much pain’ (34%) and ‘does not believe they are at risk’ (19.9%). Conclusions: Despite national guidelines, a high proportion of individuals remain undiagnosed, of which a majority are young men. Our study demonstrated high patient acceptance of ED-based HCT. There is a need for investment and innovation regarding effective pain management and confidential service delivery to address patient barriers. Findings support a routine, non-targeted HCT strategy in EDs. Keywords: HIV counselling and testing; South Africa; emergency department; patient acceptance; implementation research; linkage to care.
- Full Text:
- Authors: Aditi Rao , Caitlin Kennedy , Pamela Mda , Thomas C. Quinn , David Stead , Bhakti Hansoti
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3270 , vital:43287 , https://doi.org/10.4102/sajhivmed.v21i1.1105
- Description: Background: South Africa faces the highest burden of HIV infection globally. The National Strategic Plan on HIV recommends provider-initiated HIV counselling and testing (HCT) in all healthcare facilities. However, HIV continues to overwhelm the healthcare system. Emergency department (ED)-based HCT could address unmet testing needs. Objectives: This study examines the reasons for accepting or declining HCT in South African EDs to inform the development of HCT implementation strategies. Method: We conducted a prospective observational study in two rural EDs, from June to September 2017. Patients presenting to the ED were systematically approached and offered a point-of-care test in accordance with national guidelines. Patients demographics, presenting compaint, medical history and reasons for accepting/declining testing, were recorded. A pooled analysis is presented. Results: Across sites, 2074 adult, non-critical patients in the ED were approached; 1880 were enrolled in the study. Of those enrolled, 19.7% had a previously known positive diagnosis, and 80.3% were unaware of their HIV status. Of those unaware, 90% patients accepted and 10% declined testing. The primary reasons for declining testing were ‘does not want to know status’ (37.6%), ‘in too much pain’ (34%) and ‘does not believe they are at risk’ (19.9%). Conclusions: Despite national guidelines, a high proportion of individuals remain undiagnosed, of which a majority are young men. Our study demonstrated high patient acceptance of ED-based HCT. There is a need for investment and innovation regarding effective pain management and confidential service delivery to address patient barriers. Findings support a routine, non-targeted HCT strategy in EDs. Keywords: HIV counselling and testing; South Africa; emergency department; patient acceptance; implementation research; linkage to care.
- Full Text:
Southern African HIV Clinicians Society guidelines for antiretroviral therapy in adults: 2020 update
- Authors: David Stead
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3281 , vital:43293 , https://doi.org/10.4102/sajhivmed.v21i1.1115
- Description: What is new in the 2020 guidelines update? Key updates ÿ A recommendation for dolutegravir (DTG)-based therapies as the preferred first-line antiretroviral therapy (ART) option (section 11). ÿ Updated guidelines for second- and third-line ART regimens (section 13). ÿ New recommendations on the management of patients on DTG-based therapies who have an elevated viral load (section 12). ÿ A lowering of the threshold for virological failure from 1000 copies/mL to 50 copies/mL (section 8). ÿ A recommendation against routine cluster of differentiation 4 (CD4+) monitoring in patients who are clinically well once the CD4+ count is > 200 cells/μL (section 9). ÿ Updated recommendations for isoniazid preventive therapy (IPT) in human immunodeficiency virus (HIV)-positive patients (section 27). ÿ A recommendation for the use of low-dose prednisone as prophylaxis for paradoxical tuberculosis (TB) immune reconstitution inflammatory syndrome (IRIS) in TB/HIV co-infected patients commencing ART within 1 month of TB therapy (section 26).
- Full Text:
Southern African HIV Clinicians Society guidelines for antiretroviral therapy in adults: 2020 update
- Authors: David Stead
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3281 , vital:43293 , https://doi.org/10.4102/sajhivmed.v21i1.1115
- Description: What is new in the 2020 guidelines update? Key updates ÿ A recommendation for dolutegravir (DTG)-based therapies as the preferred first-line antiretroviral therapy (ART) option (section 11). ÿ Updated guidelines for second- and third-line ART regimens (section 13). ÿ New recommendations on the management of patients on DTG-based therapies who have an elevated viral load (section 12). ÿ A lowering of the threshold for virological failure from 1000 copies/mL to 50 copies/mL (section 8). ÿ A recommendation against routine cluster of differentiation 4 (CD4+) monitoring in patients who are clinically well once the CD4+ count is > 200 cells/μL (section 9). ÿ Updated recommendations for isoniazid preventive therapy (IPT) in human immunodeficiency virus (HIV)-positive patients (section 27). ÿ A recommendation for the use of low-dose prednisone as prophylaxis for paradoxical tuberculosis (TB) immune reconstitution inflammatory syndrome (IRIS) in TB/HIV co-infected patients commencing ART within 1 month of TB therapy (section 26).
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The association between HIV tri-therapy with the development of Type-2 Diabetes Mellitus in a rural South African district: A case-control study
- Bam, Nokwanda E, Mabunda, Sikhumbuzo A, Ntsaba, Jafta, Apalata, Teke, Monatshila, Sibusisu C, Chitha, Wesile
- Authors: Bam, Nokwanda E , Mabunda, Sikhumbuzo A , Ntsaba, Jafta , Apalata, Teke , Monatshila, Sibusisu C , Chitha, Wesile
- Date: 2020
- Subjects: Type 2 diabetes , AIDS (Disease) , Rural health
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4008 , vital:43983 , https://doi.org/10.1371/journal.pone.0244067
- Description: Combination antiretroviral drugs(cARVs)prolong patients’ lives but are unfortunately thought to increase complications related to metabolic disorders including type-2 Diabetes Mellitus(DM).We sought to confirm the association of cARVs with type-2DM and ascertain the extent of this association in a rural South African setting. A case-control study of 177 (33.33%) cases with HIV/AIDS and type-2 DM were selected and compared with 354 (66.67%) non-DM HIV/AIDS unmatched controls from a rural district of South Africa’s third most populous province (Eastern Cape). Cases were identified from community health centres using the district health information system, and controls were identified using simple random sampling from the same health facilities. Odds Ratios (OR), together with 95% confidence intervals, were calculated for all the univariable and multivariable logistic analyses. This study found that cARVs significantly increased the occurrence of type-2 DM among HIV patients. Patients on protease inhibitors (PIs) were at least 21 times significantly more likely to be diabetic than those on the fixed dose combination (FDC); those on stavudine (D4T) and zidovudine (AZT) were 2.45 times and 9.44 times respectively more likely to be diabetic than those on FDC. The odds of diabetes increased by more than three-folds for those who had been on antiretroviral drugs for more than 6 years.
- Full Text:
- Authors: Bam, Nokwanda E , Mabunda, Sikhumbuzo A , Ntsaba, Jafta , Apalata, Teke , Monatshila, Sibusisu C , Chitha, Wesile
- Date: 2020
- Subjects: Type 2 diabetes , AIDS (Disease) , Rural health
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4008 , vital:43983 , https://doi.org/10.1371/journal.pone.0244067
- Description: Combination antiretroviral drugs(cARVs)prolong patients’ lives but are unfortunately thought to increase complications related to metabolic disorders including type-2 Diabetes Mellitus(DM).We sought to confirm the association of cARVs with type-2DM and ascertain the extent of this association in a rural South African setting. A case-control study of 177 (33.33%) cases with HIV/AIDS and type-2 DM were selected and compared with 354 (66.67%) non-DM HIV/AIDS unmatched controls from a rural district of South Africa’s third most populous province (Eastern Cape). Cases were identified from community health centres using the district health information system, and controls were identified using simple random sampling from the same health facilities. Odds Ratios (OR), together with 95% confidence intervals, were calculated for all the univariable and multivariable logistic analyses. This study found that cARVs significantly increased the occurrence of type-2 DM among HIV patients. Patients on protease inhibitors (PIs) were at least 21 times significantly more likely to be diabetic than those on the fixed dose combination (FDC); those on stavudine (D4T) and zidovudine (AZT) were 2.45 times and 9.44 times respectively more likely to be diabetic than those on FDC. The odds of diabetes increased by more than three-folds for those who had been on antiretroviral drugs for more than 6 years.
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The impact of HIV knowledge and attitudes on HIV testing acceptance among patients in an emergency department in the Eastern Cape, South Africa
- Ryan, Sofia, Hahn, Elizabeth, Rao, Aditi, Mwinnyaa, George, Black, John, Nyanisa, Yandisa, Quinn, Thomas C, Hansoti, Bhakti, Maharaj, Roshen, Mvandaba, Nomzamo
- Authors: Ryan, Sofia , Hahn, Elizabeth , Rao, Aditi , Mwinnyaa, George , Black, John , Nyanisa, Yandisa , Quinn, Thomas C , Hansoti, Bhakti , Maharaj, Roshen , Mvandaba, Nomzamo
- Date: 2020
- Subjects: HIV testing , Emergency departments
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/4473 , vital:44123 , https://doi.org/10.1186/s12889-020-09170-x
- Description: Transmission of HIV in South Africa continues to be high due to a large proportion of individuals living with undiagnosed HIV. Uptake of HIV testing is influenced by a multitude of factors including the patient’s knowledge and beliefs about HIV. Methods: This study sought to quantify the impact of knowledge and attitudes on HIV testing acceptance in an emergency department by co-administering a validated HIV knowledge and attitudes survey to patients who were subsequently offered HIV testing. During the study period 223 patients were interviewed and offered HIV testing. Individuals reporting more negative overall attitudes (p = 0.006), higher levels of stigma to HIV testing, and individuals who believed their test was confidential were more likely to accept an HIV test. Interventions focused on improving patient perceptions around testing confidentiality will likely have the greatest impact on testing acceptance in the emergency department.
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- Authors: Ryan, Sofia , Hahn, Elizabeth , Rao, Aditi , Mwinnyaa, George , Black, John , Nyanisa, Yandisa , Quinn, Thomas C , Hansoti, Bhakti , Maharaj, Roshen , Mvandaba, Nomzamo
- Date: 2020
- Subjects: HIV testing , Emergency departments
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/4473 , vital:44123 , https://doi.org/10.1186/s12889-020-09170-x
- Description: Transmission of HIV in South Africa continues to be high due to a large proportion of individuals living with undiagnosed HIV. Uptake of HIV testing is influenced by a multitude of factors including the patient’s knowledge and beliefs about HIV. Methods: This study sought to quantify the impact of knowledge and attitudes on HIV testing acceptance in an emergency department by co-administering a validated HIV knowledge and attitudes survey to patients who were subsequently offered HIV testing. During the study period 223 patients were interviewed and offered HIV testing. Individuals reporting more negative overall attitudes (p = 0.006), higher levels of stigma to HIV testing, and individuals who believed their test was confidential were more likely to accept an HIV test. Interventions focused on improving patient perceptions around testing confidentiality will likely have the greatest impact on testing acceptance in the emergency department.
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But is it publishable? Mastering the MMed message
- Authors: A G Parrish , E S Grossman,
- Date: 202
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3353 , vital:43318 , http://www.samj.org.za/index.php/samj/article/view/13033
- Description: The research requirement for South African specialist registration offers opportunities and challenges. For some clinicians it may spark a lifelong interest in clinical investigation, while for many others it may provide a potential publication opportunity. Integrating the specific requirements of an MMed mini-dissertation with those of standard medical publications can be difficult for first-time authors and their supervisors; published guidance caters to full-length laboratory Master’s or doctoral research. We suggest that research is more likely to be publishable if it is locally relevant, has a clear clinical message and is coherently presented.
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- Authors: A G Parrish , E S Grossman,
- Date: 202
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3353 , vital:43318 , http://www.samj.org.za/index.php/samj/article/view/13033
- Description: The research requirement for South African specialist registration offers opportunities and challenges. For some clinicians it may spark a lifelong interest in clinical investigation, while for many others it may provide a potential publication opportunity. Integrating the specific requirements of an MMed mini-dissertation with those of standard medical publications can be difficult for first-time authors and their supervisors; published guidance caters to full-length laboratory Master’s or doctoral research. We suggest that research is more likely to be publishable if it is locally relevant, has a clear clinical message and is coherently presented.
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Iodine nutrition status in Africa: Potentially high prevalence of iodine deficiency in pregnancy even in countries classified as iodine sufficient
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Andre Pascal Kengne
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 03-8-2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3377 , vital:43336 , https://www.cambridge.org/core/journals/public-health-nutrition/article/iodine-nutrition-status-in-africa-potentially-high-prevalence-of-iodine-deficiency-in-pregnancy-even-in-countries-classified-as-iodine-sufficient/B3DCB06E75CDDD8EAD410BE090198BA4
- Description: Objective: To assess the burden of iodine deficiency in pregnancy in Africa using estimated pregnancy median urinary iodine concentration (pMUIC). Design: pMUIC for each African country was estimated using a regression equation derived by correlating the school-age children (SAC) median UIC (mUIC) and pMUIC from countries around the globe, and the SAC mUIC data for African countries obtained from the Iodine Global Network (IGN) 2017 and 2019 Score cards. Setting: Iodine deficiency was endemic in many African countries before the introduction of iodine fortification, mainly through universal salt iodisation programmes about 25 years ago. There is a scarcity of data on the level of iodine nutrition in pregnancy in Africa. Women living in settings with pMUIC below 150 μg/l are at risk of iodine deficiency-related pregnancy complications. Participants: Fifty of the fifty-five African countries that had data on iodine nutrition status. Results: A cut-off school age mUIC ≤ 175 μg/l is correlated with insufficient iodine intake in pregnancy (pregnancy mUIC ≤ 150 μg/l). Twenty-two African countries had SAC mUIC less than 175 μg/l, which correlated with insufficient iodine intake during pregnancy (pMUIC less than 150 μg/l). However, nine of these twenty-two countries had adequate iodine intake based on SAC mUIC. Conclusions: There is likely a high prevalence of insufficient iodine intake in pregnancy, including in some African countries classified as having adequate iodine intake in the general population. A SAC mUIC ≤ 175 μ
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- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 03-8-2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3377 , vital:43336 , https://www.cambridge.org/core/journals/public-health-nutrition/article/iodine-nutrition-status-in-africa-potentially-high-prevalence-of-iodine-deficiency-in-pregnancy-even-in-countries-classified-as-iodine-sufficient/B3DCB06E75CDDD8EAD410BE090198BA4
- Description: Objective: To assess the burden of iodine deficiency in pregnancy in Africa using estimated pregnancy median urinary iodine concentration (pMUIC). Design: pMUIC for each African country was estimated using a regression equation derived by correlating the school-age children (SAC) median UIC (mUIC) and pMUIC from countries around the globe, and the SAC mUIC data for African countries obtained from the Iodine Global Network (IGN) 2017 and 2019 Score cards. Setting: Iodine deficiency was endemic in many African countries before the introduction of iodine fortification, mainly through universal salt iodisation programmes about 25 years ago. There is a scarcity of data on the level of iodine nutrition in pregnancy in Africa. Women living in settings with pMUIC below 150 μg/l are at risk of iodine deficiency-related pregnancy complications. Participants: Fifty of the fifty-five African countries that had data on iodine nutrition status. Results: A cut-off school age mUIC ≤ 175 μg/l is correlated with insufficient iodine intake in pregnancy (pregnancy mUIC ≤ 150 μg/l). Twenty-two African countries had SAC mUIC less than 175 μg/l, which correlated with insufficient iodine intake during pregnancy (pMUIC less than 150 μg/l). However, nine of these twenty-two countries had adequate iodine intake based on SAC mUIC. Conclusions: There is likely a high prevalence of insufficient iodine intake in pregnancy, including in some African countries classified as having adequate iodine intake in the general population. A SAC mUIC ≤ 175 μ
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