The association between HIV tri-therapy with the development of Type-2 Diabetes Mellitus in a rural South African district: A case-control study

- Bam, Nokwanda E, Bam, Nokwanda E, Bam, Nokwanda E, Bam, Nokwanda E, Mabunda, Sikhumbuzo A, Ntsaba, Jafta, Apalata, Teke, Monatshila, Sibusisu C, Chitha, Wesile

Title
The association between HIV tri-therapy with the development of Type-2 Diabetes Mellitus in a rural South African district: A case-control study
Creator
Bam, Nokwanda E
Creator
Mabunda, Sikhumbuzo A
Creator
Ntsaba, Jafta
Creator
Apalata, Teke
Creator
Monatshila, Sibusisu C
Creator
Chitha, Wesile
Description
Combination antiretroviral drugs(cARVs)prolong patients’ lives but are unfortunately thought to increase complications related to metabolic disorders including type-2 Diabetes Mellitus(DM).We sought to confirm the association of cARVs with type-2DM and ascertain the extent of this association in a rural South African setting. A case-control study of 177 (33.33%) cases with HIV/AIDS and type-2 DM were selected and compared with 354 (66.67%) non-DM HIV/AIDS unmatched controls from a rural district of South Africa’s third most populous province (Eastern Cape). Cases were identified from community health centres using the district health information system, and controls were identified using simple random sampling from the same health facilities. Odds Ratios (OR), together with 95% confidence intervals, were calculated for all the univariable and multivariable logistic analyses. This study found that cARVs significantly increased the occurrence of type-2 DM among HIV patients. Patients on protease inhibitors (PIs) were at least 21 times significantly more likely to be diabetic than those on the fixed dose combination (FDC); those on stavudine (D4T) and zidovudine (AZT) were 2.45 times and 9.44 times respectively more likely to be diabetic than those on FDC. The odds of diabetes increased by more than three-folds for those who had been on antiretroviral drugs for more than 6 years.
Date
2020
Subject
Type 2 diabetes
Subject
AIDS (Disease)
Subject
Rural health
Type
text, article
Identifier
http://hdl.handle.net/11260/4008
Identifier
vital:43983
Identifier
https://doi.org/10.1371/journal.pone.0244067
Format
computer, online resource, application/pdf, 1 online resource (11 pages), pdf
Publisher
PLoS ONE
Language
English
Relation
PLoS ONE, Bam NE,Mabunda SA, Ntsaba J, Apalata T, Nomatshila SC, Chitha W (2020) The association between HIV tri-therapy with the development of Type-2 Diabetes Mellitus in a rural South African District: A case-control study. PLoS ONE 15(12): e0244067, PLoS ONE volume 15 number 12 2020
Rights
Publisher, Creative Commons Attribution License, Open Access https://creativecommons.org/licenses/by/4.0/
  • Hits: 3830
  • Visitors: 2817
  • Downloads: 124

Collections

Faculty of Health Sciences
Thumbnail File Description Size Format
SOURCE1 journal.pone.0244067.pdf 476 KB Adobe Acrobat PDF
  • Disclaimer
  • Privacy
  • Copyright
  • Contact