Possible dosage regimens for topical steroids assessed by vasoconstrictor assays using multiple applications
- Woodford, R, Haigh, John M, Barry, B W
- Authors: Woodford, R , Haigh, John M , Barry, B W
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6450 , http://hdl.handle.net/10962/d1006637
- Description: The bioavailabilities and activities of three amcinonide preparations and Betnovate cream were assessed using three multiple-dosage regimen vasoconstrictor assays in 10 volunteers. Applications were made once daily, twice daily and every alternate day with an initial three times daily loading dose applied on the first day only. Blanching responses first increased and then decreased due to tachyphylaxis. It is proposed that clinically the most advantageous dosage regimen is a once daily application with no loading dose.
- Full Text:
- Date Issued: 1983
- Authors: Woodford, R , Haigh, John M , Barry, B W
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6450 , http://hdl.handle.net/10962/d1006637
- Description: The bioavailabilities and activities of three amcinonide preparations and Betnovate cream were assessed using three multiple-dosage regimen vasoconstrictor assays in 10 volunteers. Applications were made once daily, twice daily and every alternate day with an initial three times daily loading dose applied on the first day only. Blanching responses first increased and then decreased due to tachyphylaxis. It is proposed that clinically the most advantageous dosage regimen is a once daily application with no loading dose.
- Full Text:
- Date Issued: 1983
Bioavailability and activity of 0.1% amcinonide preparations: comparison with proprietary topical corticosteroid formulations of differing potencies
- Authors: Woodford, R , Haigh, John M
- Date: 1979
- Language: English
- Type: text , Article
- Identifier: vital:6447 , http://hdl.handle.net/10962/d1006634
- Description: The activity of a 0.1% amcinonide cream was compared with those of selected proprietary topical corticosteroid formulations of potencies differing according to the United Kingdom (U.K.) MIMS classification (very potent, potent and moderately potent) using a standard six hour vasoconstrictor assay with multiple reading times. Statistical analysis indicated that 0.1% amcinonide cream feU within the category of a very potent preparation. Three 0.1% amcinonide formulations (cream, combination cream and combination ointment, the last two containing anti-infective agents) were equipotent in the skin-blanching test.
- Full Text:
- Date Issued: 1979
- Authors: Woodford, R , Haigh, John M
- Date: 1979
- Language: English
- Type: text , Article
- Identifier: vital:6447 , http://hdl.handle.net/10962/d1006634
- Description: The activity of a 0.1% amcinonide cream was compared with those of selected proprietary topical corticosteroid formulations of potencies differing according to the United Kingdom (U.K.) MIMS classification (very potent, potent and moderately potent) using a standard six hour vasoconstrictor assay with multiple reading times. Statistical analysis indicated that 0.1% amcinonide cream feU within the category of a very potent preparation. Three 0.1% amcinonide formulations (cream, combination cream and combination ointment, the last two containing anti-infective agents) were equipotent in the skin-blanching test.
- Full Text:
- Date Issued: 1979
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