Factors affecting specialist psychiatry training in South Africa: Bullying during specialist psychiatric training?
- Beath, Natalie, Moxley, Karis, Subramaney, Ugasvaree, Zingela, Zukiswa, Chiliza, Bonginkosi, Joska, John, Kotzé, Carla, Seedat, Soraya
- Authors: Beath, Natalie , Moxley, Karis , Subramaney, Ugasvaree , Zingela, Zukiswa , Chiliza, Bonginkosi , Joska, John , Kotzé, Carla , Seedat, Soraya
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3839 , vital:43955
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- Authors: Beath, Natalie , Moxley, Karis , Subramaney, Ugasvaree , Zingela, Zukiswa , Chiliza, Bonginkosi , Joska, John , Kotzé, Carla , Seedat, Soraya
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3839 , vital:43955
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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAPPsychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda
- Stevenson, Anne, Zingela, Zukiswa, Akena, Dickens, Stroud, Rocky E, Atwoli, Lukoye, Campbell, Megan M, Chibnik, Lori B, Kwobah, Edith, Kariuki, Symon M, Martin, Alicia R, de Menil, Victoria, Newton, Charles R J C, Sibeko, Goodman, Stein, Dan J, Teferra, Solomon, Koenen, Karestan C
- Authors: Stevenson, Anne , Zingela, Zukiswa , Akena, Dickens , Stroud, Rocky E , Atwoli, Lukoye , Campbell, Megan M , Chibnik, Lori B , Kwobah, Edith , Kariuki, Symon M , Martin, Alicia R , de Menil, Victoria , Newton, Charles R J C , Sibeko, Goodman , Stein, Dan J , Teferra, Solomon , Koenen, Karestan C
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4594 , vital:44137
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- Authors: Stevenson, Anne , Zingela, Zukiswa , Akena, Dickens , Stroud, Rocky E , Atwoli, Lukoye , Campbell, Megan M , Chibnik, Lori B , Kwobah, Edith , Kariuki, Symon M , Martin, Alicia R , de Menil, Victoria , Newton, Charles R J C , Sibeko, Goodman , Stein, Dan J , Teferra, Solomon , Koenen, Karestan C
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4594 , vital:44137
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Protocol for a prospective descriptive prevalence study of catatonia in an acute mental health unit in urban South Africa
- Zingela, Zukiswa, Cronje, Johan, Fink, Max, van Wyk, Stephanus, Stroud, Louise
- Authors: Zingela, Zukiswa , Cronje, Johan , Fink, Max , van Wyk, Stephanus , Stroud, Louise
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4610 , vital:44142
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- Authors: Zingela, Zukiswa , Cronje, Johan , Fink, Max , van Wyk, Stephanus , Stroud, Louise
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4610 , vital:44142
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Genetics of schizophrenia in the South African Xhosa
- Gulsuner, S, Stein, D J, Susser, E S, Sibeko, G, Pretorius, A, Walsh, T, Majara, L, Mndini, M M, Mqulwana, S G, Ntola, O A, Casadei, S, Zingela, Zukiswa, Nagdee, M, Ramesar, R S, King, M-C, McClellan, J M, Ngqengelele, L L, Korchina, V, van der Merwe, C, Malan, M, Fader, K M, Feng, M, Willoughby, E, Munzi, D, Andrews, H F, Gur, R C, Gibbs, R A
- Authors: Gulsuner, S , Stein, D J , Susser, E S , Sibeko, G , Pretorius, A , Walsh, T , Majara, L , Mndini, M M , Mqulwana, S G , Ntola, O A , Casadei, S , Zingela, Zukiswa , Nagdee, M , Ramesar, R S , King, M-C , McClellan, J M , Ngqengelele, L L , Korchina, V , van der Merwe, C , Malan, M , Fader, K M , Feng, M , Willoughby, E , Munzi, D , Andrews, H F , Gur, R C , Gibbs, R A
- Date: 2020
- Subjects: Schizophrenia -- Diagnosis -- Cross-cultural studies , Medical genetics , Xhosa (African people)
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4217 , vital:44044 , https://doi.org/10.1126/science.aay8833
- Description: Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.
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- Authors: Gulsuner, S , Stein, D J , Susser, E S , Sibeko, G , Pretorius, A , Walsh, T , Majara, L , Mndini, M M , Mqulwana, S G , Ntola, O A , Casadei, S , Zingela, Zukiswa , Nagdee, M , Ramesar, R S , King, M-C , McClellan, J M , Ngqengelele, L L , Korchina, V , van der Merwe, C , Malan, M , Fader, K M , Feng, M , Willoughby, E , Munzi, D , Andrews, H F , Gur, R C , Gibbs, R A
- Date: 2020
- Subjects: Schizophrenia -- Diagnosis -- Cross-cultural studies , Medical genetics , Xhosa (African people)
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4217 , vital:44044 , https://doi.org/10.1126/science.aay8833
- Description: Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.
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First-episode psychosis and substance use in an acute mental health unit
- Thungana, Yanga, Zingela, Zukiswa, van Wyk, Stefan
- Authors: Thungana, Yanga , Zingela, Zukiswa , van Wyk, Stefan
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4759 , vital:44187
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- Authors: Thungana, Yanga , Zingela, Zukiswa , van Wyk, Stefan
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4759 , vital:44187
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Predictors of consent to cell line creation and immortalisation in a South African schizophrenia genomics study
- Campbell, Megan M, de Vries, Jantina, Mqulwana, Sibonile G, Mndini, Michael M, Ntola, Odwa A, Jonker, Deborah, Malan, Megan, Pretorius, Adele, Zingela, Zukiswa, van Wyk, Stephanus, Stein, Dan J, Susser, Ezra
- Authors: Campbell, Megan M , de Vries, Jantina , Mqulwana, Sibonile G , Mndini, Michael M , Ntola, Odwa A , Jonker, Deborah , Malan, Megan , Pretorius, Adele , Zingela, Zukiswa , van Wyk, Stephanus , Stein, Dan J , Susser, Ezra
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/5232 , vital:44412
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- Authors: Campbell, Megan M , de Vries, Jantina , Mqulwana, Sibonile G , Mndini, Michael M , Ntola, Odwa A , Jonker, Deborah , Malan, Megan , Pretorius, Adele , Zingela, Zukiswa , van Wyk, Stephanus , Stein, Dan J , Susser, Ezra
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/5232 , vital:44412
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Using iterative learning to improve understanding during the informed consent process in a South African psychiatric genomics study
- Campbell, Megan M, Susser, Ezra, Mall, Sumaya, Mqulwana, Sibonile G, Mndini, Michael M, Ntola, Odwa A, Nagdee, Mohamed, Zingela, Zukiswa, Van Wyk, Stephanus, Stein, Dan J
- Authors: Campbell, Megan M , Susser, Ezra , Mall, Sumaya , Mqulwana, Sibonile G , Mndini, Michael M , Ntola, Odwa A , Nagdee, Mohamed , Zingela, Zukiswa , Van Wyk, Stephanus , Stein, Dan J
- Date: 2017
- Subjects: Informed consent (Medical law) , Patient education
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6114 , vital:45124 , https://doi.org/10.1371/journal.pone.0188466
- Description: Obtaining informed consent is a great challenge in global health research. There is a need for tools that can screen for and improve potential research participants’ understanding of the research study at the time of recruitment. Limited empirical research has been conducted in low and middle income countries, evaluating informed consent processes in genomics research. We sought to investigate the quality of informed consent obtained in a South African psychiatric genomics study. A Xhosa language version of the University of California, San Diego Brief Assessment of Capacity to Consent Questionnaire (UBACC) was used to screen for capacity to consent and improve understanding through iterative learning in a sample of 528 Xhosa people with schizophrenia and 528 controls. We address two questions: firstly, whether research participants’ understanding of the research study improved through iterative learning; and secondly, what were predictors for better understanding of the research study at the initial screening? During screening 290 (55%) cases and 172 (33%) controls scored below the 14.5 cut-off for acceptable understanding of the research study elements, however after iterative learning only 38 (7%) cases and 13 (2.5%) controls continued to score below this cut-off. Significant variables associated with increased understanding of the consent included the psychiatric nurse recruiter conducting the consent screening, higher participant level of education, and being a control. The UBACC proved an effective tool to improve understanding of research study elements during consent, for both cases and controls. The tool holds utility for complex studies such as those involving genomics, where iterative learning can be used to make significant improvements in understanding of research study elements. The UBACC may be particularly important in groups with severe mental illness and lower education levels. Study recruiters play a significant role in managing the quality of the informed consent process.
- Full Text:
- Authors: Campbell, Megan M , Susser, Ezra , Mall, Sumaya , Mqulwana, Sibonile G , Mndini, Michael M , Ntola, Odwa A , Nagdee, Mohamed , Zingela, Zukiswa , Van Wyk, Stephanus , Stein, Dan J
- Date: 2017
- Subjects: Informed consent (Medical law) , Patient education
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6114 , vital:45124 , https://doi.org/10.1371/journal.pone.0188466
- Description: Obtaining informed consent is a great challenge in global health research. There is a need for tools that can screen for and improve potential research participants’ understanding of the research study at the time of recruitment. Limited empirical research has been conducted in low and middle income countries, evaluating informed consent processes in genomics research. We sought to investigate the quality of informed consent obtained in a South African psychiatric genomics study. A Xhosa language version of the University of California, San Diego Brief Assessment of Capacity to Consent Questionnaire (UBACC) was used to screen for capacity to consent and improve understanding through iterative learning in a sample of 528 Xhosa people with schizophrenia and 528 controls. We address two questions: firstly, whether research participants’ understanding of the research study improved through iterative learning; and secondly, what were predictors for better understanding of the research study at the initial screening? During screening 290 (55%) cases and 172 (33%) controls scored below the 14.5 cut-off for acceptable understanding of the research study elements, however after iterative learning only 38 (7%) cases and 13 (2.5%) controls continued to score below this cut-off. Significant variables associated with increased understanding of the consent included the psychiatric nurse recruiter conducting the consent screening, higher participant level of education, and being a control. The UBACC proved an effective tool to improve understanding of research study elements during consent, for both cases and controls. The tool holds utility for complex studies such as those involving genomics, where iterative learning can be used to make significant improvements in understanding of research study elements. The UBACC may be particularly important in groups with severe mental illness and lower education levels. Study recruiters play a significant role in managing the quality of the informed consent process.
- Full Text:
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